Vascular Biology & Autonomic Studies Lab

Hypertension spans across all the socioeconomic classes and ethnicities. Presenting with vague or no symptoms but associated with profound morbidity and mortality it is rightly termed the silent killer. Hypertension for several decades has been the most prevalent cardiovascular disease and the leader in all cause mortality. While the prevalence rate of hypertension is increasing, the awareness and control rate have been suboptimal and by the sixth decade of life hypertension is not only more prevalent but also less well controlled and more severe in women.

The Vascular Biology and Autonomic Studies Laboratories (VBASL) are located in Leon Levine Hall (LLHS 118C and 118D) and are directed by Dr. Scott Collier. The primary research of these labs investigates how exercise lowers blood pressure and how treatments such as antioxidant supplementation and chronic exercise can sustain the positive benefits. Combining the expertise of several faculty within the university, the synergistic effect is shown by diverse research topics.

The laboratories are equipped with state-of-the-art research equipment to study the human vasculature, beat-to-beat blood pressure control and even how the brain modulates our heart rate. The research focus allows the community to participate in these important trials as the researchers focus on diseases such as hypertension, cancer and atherosclerosis. While exercise is a main prevention and treatment, these labs also investigate how sleep is affected by exercise and blood pressure changes.

While cutting edge research is completed in these labs, they also serve as teaching facilities for both graduate and undergraduate students. These facilities are home to the Exercise Science Undergraduate Cardiovascular Research Team that has already had one Nationally recognized American Physiological Society Research Fellow and another internally funded scholar that are working on a project that investigates the effects of anti-oxidant supplementation on blood pressure following exercise. Students continue to be an important part of these laboratories and will complete senior capstone and Masters Theses here.

Recently, we have shown direct vascular and blood pressure benefits when individuals ingested a proprietary quercetin and multi-flavonoid supplement. Our next project will investigate these new-found benefits in hypertensives and if the results are as beneficial as the pilot data, we will be able to treat some cases of elevated blood pressure with a neutraceutical that has not shown any side effects yet a multitude of health benefits. Further, we are going to add some psychosocial aspects to our studies to delineate how lifestyle changes with the addition of behavioral treatments will further aid reductions in blood pressure.

Contact Information

Scott R. Collier, PhD, FACSM
Director; Vascular Biology and Autonomic Studies Laboratories
Leon Levine Hall of Health Sciences 432 D
Phone: (828) 262-7145
Email: colliersr@appstate.edu

CIMT